BackgroundThe biopharmaceutical industry operates at the intersection of life sciences, clinical research, clinical care, public health, and business, which presents distinct operational and ethical challenges. This setting merits focused bioethics consideration to complement legal compliance and business ethics efforts. However, bioethics as applied to a biopharmaceutical industry setting often is construed either too broadly or too narrowly with little examination of its proper scope.Main textAny institution with a scientific or healthcare mission should engage bioethics norms to navigate ethical issues that (...) arise from the conduct of biomedical research, delivery of clinical care, or implementation of public health programs. It is reasonable to assume that while bioethics norms must remain constant, their application will vary depending on the characteristics of a given setting. Context “specification” substantively refines ethics norms for a particular discipline or setting and is an expected, needed and progressive ethical activity. In order for this activity to be meaningful, the scope for bioethics application and the relevant contextual factors of the setting need to be delineated and appreciated. This paper defines biopharmaceutical bioethics as: the application of bioethics norms (concepts, principles, and rules) to the research, development, supply, commercialization, and clinical use of biopharmaceutical healthcare products. It provides commentary on this definition, and presents five contextual factors that need to be considered when applying bioethics norms to a biopharmaceutical industry setting: (1) dual missions; (2) timely and pragmatic guidance; (3) resource stewardship; (4) multiple stakeholders; and (5) operational complexity.ConclusionUnderstanding the scope of the biopharmaceutical enterprise and contextual factors of a biopharmaceutical industry setting is foundational for the application of bioethics norms. Establishing a common language and approach for biopharmaceutical bioethics will facilitate breadth and depth of discussion and subsequent implementation to benefit patients, the healthcare system and society. (shrink)

One of many writers inspired by Laurence Sterne's Tristram Shandy, the German novelist Jean Paul Richter coined the term 'Shandean humour' in his work of aesthetic theory. The essays in this volume investigate how Sterne's humour functions, the reasons for its enduring appeal, and what role it played in identity-construction and in the representation of melancholy. In tracing its hitherto under-recognised impact both on literary writers, such as Jean Paul and Herman Melville, and on philosophers, including Hegel and Marx, the (...) collection reveals that Shandean humour is a Grenzgänger - a point of commerce not only between Anglophone and German discourses, but also between literature and philosophy.Klaus Vieweg is Professor of Philosophy at the Friedrich Schiller University of Jena; James Vigus is postdoctoral research fellow at the Department of English and American Studies, Ludwig Maximilian University of Munich; Kathleen M. Wheeler is Reader in English Literature at the University of Cambridge. (shrink)

The New in the title of this volume alerts us to the fact that it has a predecessor, namely the 1996 Cambridge Companion to Nietzsche edited by Bernd Magnus and Kathleen M. Higgins. The two volumes...

In “Some Remarks on Extending and Interpreting Theories with a Partial Truth Predicate”, Reinhardt [21] famously proposed an instrumentalist interpretation of the truth theory Kripke–Feferman ( $\mathrm {KF}$ ) in analogy to Hilbert’s program. Reinhardt suggested to view $\mathrm {KF}$ as a tool for generating “the significant part of $\mathrm {KF}$ ”, that is, as a tool for deriving sentences of the form $\mathrm{Tr}\ulcorner {\varphi }\urcorner $. The constitutive question of Reinhardt’s program was whether it was possible “to justify the (...) use of nonsignificant sentences entirely within the framework of significant sentences”. This question was answered negatively by Halbach & Horsten [10] but we argue that under a more careful interpretation the question may receive a positive answer. To this end, we propose to shift attention from $\mathrm {KF}$ -provably true sentences to $\mathrm {KF}$ -provably true inferences, that is, we shall identify the significant part of $\mathrm {KF}$ with the set of pairs $\langle {\Gamma, \Delta }\rangle $, such that $\mathrm {KF}$ proves that if all members of $\Gamma $ are true, at least one member of $\Delta $ is true. In way of addressing Reinhardt’s question we show that the provably true inferences of suitable $\mathrm {KF}$ -like theories coincide with the provable sequents of matching versions of the theory Partial Kripke–Feferman ( $\mathrm {PKF}$ ). (shrink)

The aim of this article is twofold. First, it is argued that while the principle of ‘ought implies can’ is certainly plausible in some form, it is tempting to misconstrue it, and that this has happened in the way it has been taken up in some of the current literature. Second, Kant's understanding of the principle is considered. Here it is argued that these problematic conceptions put the principle to work in a way that Kant does not, so that there (...) is an important divergence here which can easily be overlooked. (shrink)

[INTRODUCTION] Like the terms 'dialectic', 'Aufhebung' (or 'sublation'), and 'Geist', the term 'concrete universal' has a distinctively Hegelian ring to it. But unlike these others, it is particularly associated with the British strand in Hegel's reception history, as having been brought to prominence by some of the central British Idealists. It is therefore perhaps inevitable that, as their star has waned, so too has any use of the term, while an appreciation of the problematic that lay behind it has seemingly (...) vanished: if the British Idealists get any sort of mention in a contemporary metaphysics book (which is rarely), it will be Bradley's view of relations or truth that is discussed, not their theory of universals, so that the term has a rather antique air, buried in the dusty volumes of Mind from the turn of the nineteenth century. This is not surprising: the episode known as British Idealism can appear to be a period that is lost to us, in its language, points of historical reference (Lotze, Sigwart, Jevons), and central preoccupations (the Absolute). Even while interest in Hegel continues to grow, interest in his Logic has grown more slowly than in the rest of his work, with Book III of the Logic remaining as the daunting peak of that challenging text - while it is here that the British Idealists focussed their attention and claimed to have uncovered that 'exotic' but 'vanished specimen', the concrete universal. Finally, as the trend of reading Hegel pushes ever further in a non-metaphysical direction, it might be thought that the future of the concrete universal is hardly likely to be brighter than its recent past - for it may seem hard to imagine how a conception championed by the British Idealists, who were apparently shameless in their metaphysical commitments, can find favour in these more austere and responsible times. In this paper, however, I want to make a case for holding that there is something enlightening to be found in how some of the British Idealists approached the 'concrete universal', both interpretatively and philosophically. At the interpretative level, I will argue that while not everything these Idealists are taken to mean by the term is properly to be found in Hegel, their work nonetheless relates to a crucial and genuine strand in Hegel's position, so that their discussion of this issue is an important moment in the reception history of his thought. At a philosophical level, I think that the question that concerned Hegel and these British Idealists retains much of its interest, as does their shared approach to it: namely, how far does our thought involve a mere abstraction from reality, and what are the metaphysical and epistemological implications if it turns out it does not? As such, I will suggest, taking seriously what these British Idealists have to say about the concrete universal can help us both in our understanding of Hegel, and in our appreciation of the contribution Hegel's position can make to our thinking on the issues that surround this topic. (shrink)

Banks face a dilemma in choosing between maximising profits and facilitating the sustainable use of resources within a carbon-constrained future. This study provides empirical evidence on this dilemma, investigating whether a bank loan announcement for a firm with high carbon risk conveys information to investors about the firm’s carbon risk exposure collected through a bank’s pre-loan screening and ongoing monitoring. We use a sample of 120 bank loan announcements for ASX-listed firms over the period 2009–2015. We measure high carbon risk (...) exposure based on whether firms meet the reporting threshold of the NGER scheme. We document positive and significant excess loan announcement returns for loan renewals for high carbon risk firms, but not for loan initiations. Further, we document a more significant loan announcement return for renewals with favourable term revisions. Finally, we find no evidence that the market differentiates between domestic and foreign lenders. Taken together, our results suggest that investors perceive that banks incorporate carbon risk considerations into their lending decisions. Our results highlight the value of banks as financial intermediaries given the information asymmetry surrounding firms’ carbon risk exposure, and more generally the need to extend modern banking theory to consider issues such as the impact of banks’ CSR reputation on lending decisions. (shrink)

A modest transcendental argument is one that sets out merely to establish how things need to appear to us or how we need to believe them to be, rather than how things are. Stroud's claim to have established that all transcendental arguments must be modest in this way is criticised and rejected. However, a different case for why we should abandon ambitious transcendental arguments is presented: namely, that when it comes to establishing claims about how things are, there is no (...) reason to prefer transcendental arguments to arguments that rely on the evidence of the senses, making the former redundant in a way that modest transcendental arguments, which have a different kind of sceptical target, are not. (shrink)

Government lawyers and other public officials sometimes face an excruciating moral dilemma: to stay on the job or to quit, when the government is one they find morally abhorrent. Staying may make them complicit in evil policies; it also runs the danger of inuring them to wrongdoing, just as their presence on the job helps inure others. At the same time, staying may be their only opportunity to mitigate those policies – to make evils into lesser evils – and to (...) uphold the rule of law when it is under assault. This Article explores that dilemma in a stark form: through the moral biographies of two lawyers in the Third Reich, both of whom stayed on the job, and both of whom can lay claim to mitigating evil. One, Helmuth James von Moltke, was an anti-Nazi, and a martyr of the resistance; the other, Bernhard Lösener, was a Nazi by conviction who nevertheless claimed to have secretly fought against the persecution of Jews from the improbable post of legal adviser on Jewish matters. The Article critically examines their careers and self-justifications. It frames its analysis through two philosophical arguments: Hannah Arendt’s stern injunction that staying on the job is self-deception or worse, because like it or not, obedience is support; and a contemporary analysis of moral complicity by Chiara Lepora and Robert Goodin. The chief question, with resonance today as well as historically, is whether Arendt is right – and, if not, under what conditions lesser-evilism can succeed. This article will appear in a symposium with comments by Leora Bilsky and Natalie Davidson, Kathleen Clark, Erica Newland, and Shannon Prince. (shrink)

In this article, I want to argue that scepticism for Kant must be seen in ancient and not just modern terms, and that if we take this into account we will need to take a different view of Kant's response to Hume from the one that is standardly presented in the literature. This standard view has been put forward recently by Paul Guyer, and it is therefore his view that I want to look at in some detail, and to try (...) to correct. (shrink)

This paper focuses on one of C. S. Peirce's criticisms of G. W. F. Hegel: namely, that Hegel neglected to give sufficient weight to what Peirce calls "Secondness", in a way that put his philosophical system out of touch with reality. The nature of this criticism is explored, together with its relevant philosophical background. It is argued that while the issues Peirce raises go deep, in some respects Hegel's position is closer to his own than he may have realised, whilst (...) in others that criticism can be resisted by the Hegelian. (shrink)

The aim of this paper is to criticize Thomas Baldwin's claim, that in developing an identity theory of truth, F H Bradley was following Hegel. It is argued that Baldwin has incorrectly understood certain passages from Hegel which he cites in defense of this view, and that Hegel's conception of truth was primarily material, not propositional.

The "standard account" of Wittgenstein’s relations with the Vienna Circle is that the early Wittgenstein was a principal source and inspiration for the Circle’s positivistic and scientific philosophy, while the later Wittgenstein was deeply opposed to the logical empiricist project of articulating a "scientific conception of the world." However, this telegraphic summary is at best only half-true and at worst deeply misleading. For it prevents us appreciating the fluidity and protean character of their philosophical dialogue. In retrospectively attributing clear-cut positions (...) to Wittgenstein and his interlocutors, it is very easy to read back our current understanding of familiar distinctions into a time when those terms were used in a much more open-ended way. The paper aims to to provide a broader perspective on this debate, starting from the protagonists’ understanding of their respective positions. Too often, the programmatic statements about the nature of their work that are repeated in manifestoes, introductions, and elementary textbooks have occupied center stage in the subsequent secondary literature. Consequently, I focus on a detailed examination of a turning point in their relationship. That turning point is Wittgenstein's charge, in the summer of 1932, that a recently published paper of Carnap's, "Physicalistic Language as the Universal Language of Science", made such extensive and unacknowledged use of Wittgenstein's own ideas that Wittgenstein would, as he put it in a letter to Schlick, "soon be in a situation where my own work shall be considered merely as a reheated version or plagiarism of Carnap’s." While the leading parties in this dispute shared a basic commitment to the primacy of physicalistic language, and the view that all significant languages are translatable, there was a remarkable lack of mutual understanding between them, and deep disagreement about the nature of the doctrines they disputed. Three quarters of a century later, we are so much more conscious of the differences that separated them than the points on which they agreed that it takes an effort of historical reconstruction to appreciate why Wittgenstein once feared that his own work would be regarded as a pale shadow of Carnap’s. (shrink)

Plato's "Ion," despite its frail frame and traditionally modest status in the corpus, has given rise to large exegetical claims. Thus some historians of aesthetics, reading it alongside page 205 of the Symposium, have sought to identify in it the seeds of the post-Kantian notion of 'art' as non-technical making, and to trace to it the Romantic conception of the poet as a creative genius. Others have argued that, in the "Ion," Plato has Socrates assume the existence of a technē (...) of poetry. In this article, these claims are challenged on exegetical and philosophical grounds. To this effect, Plato's use of poiētēs and poiēsis in the Symposium is analysed, the defining criteria of technē in the "Ion" and other dialogues are identified and discussed, and the 'Romantic' interpretation of the dialogue is traced to Shelley's tendentious translation of it. These critical developments lead to what is presented as a more faithful reading of the dialogue. In the "Ion," it is claimed, Plato seeks to subvert the traditional status of poetry by having Socrates argue that poetry is both non-rational and non-cognitive in nature. In the third part of the article, suggestions are offered as to the contribution made by the "Ion" to the evolution of Plato's reflections on poetic composition, and particularly as to the reasons which later induced Plato to substitute the concept of mimesis for that of inspiration in his account of poetry. (shrink)

: This paper offers a distinctive interpretation of Hegel's Doppelsatz from the Preface to the Philosophy of Right: 'What is rational is actual; and what is actual is rational'. This has usually been interpreted either conservatively (as claiming that everything that is, is right or good) or progressively (that if the world were actual, it would be right or good, but that there is a distinction that can be drawn between existence and actuality). My aim in this paper is to (...) argue against both interpretations, so that the position I offer is neutral between the two. My claim is that when Hegel identifies what is actual with what is rational in the Doppelsatz, his intention is not to offer a normative assessment of what is actual; rather, it is to suggest that genuine philosophy must be committed to reason in its methods of inquiry, if it is to properly undertake an investigation into the "spiritual universe" as well as the "natural" one. The Doppelsatz is thus a defence of philosophical rationalism, rather than a normative claim about "was ist wirklich". (shrink)

The Kant-Hegel relation has a continuing fascination for commentators on Hegel, and understandably so: for, taking this route into the Hegelian jungle can promise many advantages. First, it can set Hegel’s thought against a background with which we are fairly familiar, and in a way that makes its relevance clearly apparent; second, it can help us locate Hegel in the broader philosophical tradition, making us see that the traditional ‘analytic’ jump from Kant to Frege leaves out a crucial period in (...) post-Kantian thought; third, it can show Hegel in a progressive light, as attempting to take that tradition further forward; fourth, it can help us locate familiar philosophical issues in Hegelian thought that otherwise can appear wholly sui generis; and finally, and perhaps most importantly of all, focusing on this relation can help raise and crystalise some of the fascinating ambiguities concerning Hegel’s outlook, regarding whether Hegel’s response to Kant shows him to have been a reactionary, Romantic, pre-critical thinker, who sought to turn the philosophical clock back to a time before Kant had written, or a modernist, Enlightened and essentially critical one, who remained true to the spirit if not the letter of Kant’s philosophy. (shrink)

This article defends psychology and psychoanalysis against the accusation that their use of anthropomorphism in descriptions of brain and mind reintroduces the 'little man in the brain' and generates a viciously circular analysis. It queries the clarity of the concept 'anthropomorphic', And argues that many predicates which are allegedly 'characteristically human' are freely and literally attributable to machines, Parts of the brain, Etc.; this merely points out the unsurprising fact that non-Humans often perform tasks which humans can also perform. It (...) does not make these non-Humans into intelligent man-Analogues. (shrink)

The aim of this volume is to open up new perspectives and to raise new research questions about a unified approach to truth, modalities, and propositional attitudes. The volume's essays are grouped thematically around different research questions. The first theme concerns the tension between the theoretical role of the truth predicate in semantics and its expressive function in language. The second theme of the volume concerns the interaction of truth with modal and doxastic notions. The third theme covers higher-order solutions (...) to the semantic and modal paradoxes, providing an alternative to first-order solutions embraced in the first two themes. This book will be of interest to researchers working in epistemology, logic, philosophy of logic, philosophy of language, philosophy of mathematics, and semantics. (shrink)

In Defense of Religious Liberty contains David Novak’s vigorous—and paradoxical—argument that the primacy of divine law is the best foundation for a secular, multicultural democracy. Novak presents his claim, which will astound both liberal and conservative advocates of democracy, in political, philosophical, and theological terms. He shows how the universal norms of divine law are knowable as natural law, that they are the best formulations of the human rights of life, liberty, and the pursuit of happiness, and that (...) their assertion includes an explicit recognition of God as cosmic lawgiver. Furthermore, Novak maintains that the seemingly disparate ideas of divine command, natural law, and human rights can be integrated into one overall political theory. Novak reveals this integration at work in the classical texts of his own Jewish tradition, as well as in the canonical philosophical tradition of the West, from Plato to the Stoics to Grotius to Kant. He also convincingly makes the case that those who reject any legitimate role for religion in discussions of public morality inevitably substitute arbitrary human power for divine command, arbitrary positive law for natural law, and arbitrary governmental entitlements for human rights that exist prior to the establishment of the state. Novak concludes that religious traditions like Judaism, precisely because they incorporate the doctrines of God the cosmic lawgiver, natural law, and human rights, provide the most coherent ontological foundation for democracy in today’s world. (shrink)

The deconstruction of the subject associated with postmodernism cannot be said to have simply carried the day. Opponents and critics of postmodernism have held that we must return to the subject and to autonomy as a necessary condition of thinking about ethics, politics, agency and responsibility. Indeed, Peter Dews has recently argued that efforts to displace the subject repeat rather than dissolve the problems generated by subject-centered theories, a charge he takes to be devastating. The implications of this return to (...) the subject, and the power of the critique which motivates it, will be my focus here. I consider especially Judith Butler's performative account of agency and her recent discussion of reflexivity, and argue that they afford us a means of obviating the critique while providing for the reflexive agency that proponents of the return to the subject think necessary. Key Words: agency • autonomy • Seyla Benhabib • Judith Butler • Dieter Henrich • power • reflexivity • subjectivation • subjectivity. (shrink)

In Being and Nothingness Jean-Paul Sartre contends that the self's fundamental relation with the other is one of inescapable conflict. I argue that the research of the last few decades on the ability of infants - even newborns - to imitate the facial expressions and gestures of adults provides counter-evidence to Sartre's claim. Sartre is not wrong that the look of the other may be a source of self-alienation, but that is not how it functions in the first instance. An (...) earlier and more primary form of looking with and at the other is a source of self-discovery. In early imitation, the infant and adult each see the other not as objects of experience but as subjects of action. Such looking is necessary for the infant to realize its own potential as a self-conscious, goal-directed subject of perception and action. (shrink)

Many recent gene knockout experiments cause anatomical changes to the jaw region of mice that several investigators claim are evolutionary reversals. Here we evaluate these mutant phenotypes and the assertions of atavism. We argue that following the knockout of Hoxa-2, Dlx-2, MHox, Otx2, and RAR genes, ectopic cartilages arise as secondary consequences of disruptions in normal processes of cell specification, migration, or differentiation. These disruptions cause an excess of mesenchyme to accumulate in a region through which skeletal progenitor cells usually (...) migrate, and at a site of condensation that is normally present in mammals but that is too small to chondrify. We find little evidence that these genes, when disrupted, cause a reversion to any primitive condition and although changes in their expression may have played a role in the evolution of the mammalian jaw, their function during morphogenesis is not sufficiently understood to confirm such hypotheses. BioEssays 20:245–255, 1998.© 1998 John Wiley & Sons, Inc. (shrink)

We introduce a notion of complexity for interpretations, which is used to prove some new results about interpretations of sequential theories. In particular, we give a new, elementary proof of Pudlák's theorem that sequential theories are connected. We also demonstrate a counterexample to the infinitary distributive law $a \vee \bigwedge_{i \in I} b_i = \bigwedge_{i \in I} (a \vee b_i)$ in the lattice of chapters, in which the chapters a and b i are compact. (Counterexamples in which a is not (...) compact have been found previously.). (shrink)